A Once-Weekly Oral Peptide Enters Human Testing
Gan & Lee's GZC8072 is an investigational once-weekly oral GLP-1 peptide. Explore its Phase 1 milestone, delivery challenges, and unanswered questions.
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Drug Delivery
The practical problem of getting peptides into the body and keeping them there: oral and nasal formulations, long-acting chemistry, half-life extension and injection routes. Coverage notes which approaches are approved, which are in trials and which remain preclinical.
6 articles by Brian Gossett. Read our editorial standards.
Why Long-Acting Peptides Are Becoming a Pharmaceutical Priority
How lipidation, albumin binding, PEG alternatives, and depot technology extend peptide half-life to enable weekly and monthly dosing — and why pharma invests.
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Nasal Peptides Are Expanding: Delivery Straight Toward the Brain
Why nasal peptides are expanding: how nose-to-brain delivery works around the blood-brain barrier, plus Semax, Selank, oxytocin, and intranasal GLP-1 research.
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Oral Peptides Are Having a Breakthrough Year
Why oral peptide drugs are finally working: enteric coatings, permeation enhancers, and landmark approvals like oral semaglutide and octreotide, explained.
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The Complete Guide to Peptide Half-Life
A complete guide to peptide half-life: what it means, plasma vs terminal half-life, why native peptides clear in minutes, how it's measured, and half-life extension.
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How to Use Semax Nasal Spray (Dosage + Timing)
Complete guide to Semax nasal spray: why nasal delivery reaches the brain faster, dosage (50–100mcg per nostril), timing for focus vs sleep, correct spray technique, and storage.
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